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The Cape Romain National Wildlife Refuge is a 66,287 acre (267 km) National Wildlife Refuge in southeastern South Carolina near Awendaw, South Carolina. The refuge lands and waters encompass water impoundments, creeks and bays, emergent salt marsh and barrier islands. 29,000 acres (120 km2) are designated as a wilderness area. Most of the refuge is accessible only by boat. The Intracoastal Waterway passes the Refuge. Mainland facilities include the refuge's headquarters and visitor center which are located on U.S. Highway 17 about 30 minutes by car from Charleston, South Carolina.

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